Every ingredient, on the table

The research behind ClearMind+

Nine ingredients, and the honest state of the science on each — including where the evidence is strong, where it's still early, and where it's mostly traditional. We show you the research on the ingredients; we don't dress it up as proof about the gummy.

Human trials exist Mostly preclinical (lab/animal) Authorised health claim Two of the nine — B5 & iodine — carry officially authorised claims; the rest is shown as ingredient research & traditional use.

Lion's Mane

Hericium erinaceus

Fruiting body 5:1 extract Hericenones & erinacines

Human trials — early

800+Publications

~6Human cognition trials

The most-researched functional mushroom for the brain, and the reason ClearMind+ exists. Its hericenones and erinacines are the focus of ongoing research into the nervous system. Human evidence is still early — a small number of trials, strongest in older adults and more mixed in healthy younger people — which is exactly why we say studied, not proven.

Selected human studies Mori et al. (2009), Phytotherapy Research — 16-week trial, mild cognitive impairment · Docherty et al. (2023), Nutrients · Surendran et al. (2025), Frontiers in Nutrition

Cordyceps

Cordyceps militaris / sinensis

Mycelium Cordycepin

Human trials

14+Human trials (athletes)

Ours is grown as mycelium — standard for cordyceps, since wild fruiting body is prohibitively rare — and we'd rather tell you that than imply otherwise. It's the most-studied mushroom for exercise and oxygen use: a 2025 meta-analysis pooled 14 human trials in athletes looking at endurance and aerobic capacity.

Selected human studies Systematic review & meta-analysis (2025), Frontiers in Nutrition · Marathoner RCT (2022), J. Herbal Medicine

Reishi

Ganoderma lucidum

Fruiting body 20:1 extract Triterpenes & beta-glucans

Human trials — other outcomes

3,000+Publications

One of the most-studied medicinal mushrooms of all, with thousands of papers. Human trials do exist, but they cluster on immune and cardiovascular outcomes rather than focus — so we include reishi as part of the adaptogenic base and present its research honestly, without a cognition claim.

Selected human studies GRADE-assessed systematic review of clinical trials (2025)

Maitake

Grifola frondosa

Fruiting body 10:1 extract Beta-glucans

Mostly preclinical

Our most concentrated extract at 10:1. Maitake is researched largely for its beta-glucans, mainly in lab and animal studies; direct human cognitive data is limited. It's in the blend for its formulation profile, and we're upfront that the evidence here is still preclinical.

Evidence base Primarily preclinical (in-vitro and animal) research on beta-glucans.

Chaga

Inonotus obliquus

Fruiting body 20:1 extract Polysaccharides & betulin

Mostly preclinical

Chaga is studied mainly for its antioxidant compounds. The honest position: this evidence is almost entirely preclinical, with very little human data. It's part of the blend for its antioxidant profile — not the basis of any cognitive claim, and we won't pretend otherwise.

Evidence base Primarily preclinical (in-vitro and animal) antioxidant research.

Tremella

Tremella fuciformis

Fruiting body 200:1 extract Polysaccharides

Mostly preclinical / traditional

Long used in East-Asian skincare traditions for its hydrating polysaccharides. Most of the modern evidence is preclinical, so tremella earns its place here on its traditional-use story and formulation role rather than a health claim.

Evidence base Traditional use; primarily preclinical research on polysaccharides.

Panax Ginseng

Panax ginseng C.A. Meyer

Root extract Ginsenosides

Human trials

DozensHuman RCTs

Not a mushroom — a root with one of the largest evidence bases of any botanical, including dozens of human trials investigating cognition and fatigue. Like the mushrooms, its health claims sit "on hold" under UK rules, so we present the research rather than a promise.

Selected human studies Ginseng & cognition meta-analysis (2024), Phytotherapy Research · Kim et al. (2013), PLOS One — anti-fatigue RCT

Vitamin B5

Pantothenic acid

Essential nutrient

Authorised health claim

One of the two ingredients we're officially permitted to make benefit claims about — so this is where our real functional language lives.

Authorised: Pantothenic acid contributes to normal mental performance, and to the reduction of tiredness and fatigue.

Status Authorised on the GB Nutrition & Health Claims Register (subject to minimum-content conditions).

Iodine

Essential mineral

Essential nutrient

Authorised health claim

The second ingredient carrying authorised claims — and the other anchor for what we're allowed to say as a genuine benefit.

Authorised: Iodine contributes to normal cognitive function, to the normal functioning of the nervous system, and to normal energy-yielding metabolism.

Status Authorised on the GB Nutrition & Health Claims Register (subject to minimum-content conditions).

Why we talk about it this way

In the UK, health claims for mushrooms and botanicals are officially "on hold" — meaning no brand is allowed to claim they treat or improve anything, however many studies exist. The figures and studies on this page describe research on the individual ingredients, not clinical trials of ClearMind+ itself.

So we do the honest thing: we show you the science and the traditional use, we name our forms and extract ratios, and we keep our actual benefit claims to the two ingredients — Vitamin B5 and iodine — that are officially authorised. No borrowed proof, no asterisks doing the heavy lifting.

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